Americans David Julius and Ardem Patapoutian identified receptors in the skin that respond to heat and pressure.
Patapoutian, who was born in Lebanon and now works at Scripps Research Institute at La Jolla, California, found separate pressure-sensitive sensors in cells that respond to mechanical stimulation, it said.
Perlmann said he managed to get hold of both of the winners — who shared the prestigious Kavli Award for Neuroscience last year — before Monday’s announcement. “I only had a few minutes to talk to them, but they were incredibly happy,” he said. “And as far as I could tell they were very surprised and a little bit shocked, maybe.”
The choice of Julius, 65, and Patapoutian underscored how little scientists knew about how our bodies perceive the external world before their discoveries — and how much there still is to learn, said Oscar Marin, director of the MRC Centre for Neurodevelopmental Disorders at King’s College London. “While we understood the physiology of the senses, what we didn’t understand was how we sensed differences in temperature or pressure,” Marin said. “Knowing how our body senses these changes is fundamental because once we know those molecules, they can be targeted. It’s like finding a lock and now we know the precise keys that will be necessary to unlock it.”press conference shortly after finding out the happy news.
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