3,3′-Diindolylmethane (DIM) decreased the Streptococcus mutans biofilm, a leading contributor to plaque and cavities, by 90%. A significant portion of the global population experiences persistent issues with dental plaque and cavities or will face them at some time. While toothpaste, mouthwash, and
, have identified that 3,3′-Diindolylmethane – a naturally occurring molecule also referred to as bisindole – can reduce biofilms responsible for plaque and cavities by a remarkable 90%.Their findings were recently published in the journal, which is believed to be one of the primary actors in dental cavities.grows in the moist and sugary atmosphere of your mouth after food in a biofilm that coats your teeth. Biofilm generates plaque, attacks enamel, and causes cavities.
“The molecule, which was found to have low toxicity, could be added to toothpastes and mouthwashes to greatly improve dental hygiene,” says lead author Prof. Ariel Kushmaro of the Avram and Stella Goldstein-Goren Department of Biotechnology Engineering. He is also a member of the Ilse Katz Institute for Nanoscale Science and Technology and the Goldman Sonnenfeldt School of Sustainability and Climate Change.
Biofilm” by Yifat Baruch, Karina Golberg, Qun Sun, Karina Yew-Hoong Gin, Robert S. Marks and Ariel Kushmaro, 6 June 2023,
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