Tuberculosis (TB) is usually found in the lungs, but there's an ancient lineage of TB that specializes in spreading to the bones and damaging them from the inside, researchers have discovered.
– immune cells that swallow pathogens. Stout and Tobin wanted to find out what makes some types of TB more mobile inside the human body than other types of TB., the researchers compare the genetic sequence of the TB strain responsible for the North Carolina outbreak with 225 other strains of TB.
Today, the lineage 1 strain is responsible for a large burden of disease, but is geographically restricted to countries that border the Indian Ocean. A previous study from the UK of over 1,600 people suggested that lineage 1 TB was associated with higher rates of skeletal TB than the 'modern' lineages.
They then infected a separate group of zebrafish with a TB strain that contained a mutant EsxM variant. The travel distance of macrophages infected with a mutant TB strain was two-fold shorter than those with the full-length EsxM variant.
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