Leipzig researchers examine a new cause of severe obesity. Obesity and obesity-related illnesses are major contributors to global mortality, but the root causes are still not well known. Several factors contribute to the development and progression of the disease, including genetics. In most cases,
Given the discovery, the researchers suggest reevaluating the methods used to diagnose patients with hereditary obesity.Obesity and obesity-related illnesses are major contributors to global mortality, but the root causes are still not well known. Several factors contribute to the development and progression of the disease, including genetics.
While studying tissue samples from a girl with severe obesity, the Leipzig researchers found that a specific gene, the agouti-signaling protein gene, was produced at high levels in cells where it is not normally present . The type of mutation found in the current study escapes standard genetic screening algorithms, which means that it remains undetected in many affected patients. Thanks to the targeted screening of the Leipzig Childhood Obesity cohort, Professor Körner’s team has identified four additional patients with the same mutation.
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