Nature research paper: A naturally inspired antibiotic to target multidrug-resistant pathogens
. The bacterial natural product colistin is considered the last line of defence against a number of Gram-negative pathogens. The recent global spread of the plasmid-borne mobilized colistin-resistance gene. Bacteria-derived antibiotics often appear in nature as collections of similar structures that are encoded by evolutionarily related biosynthetic gene clusters.
. In a mouse neutropenic infection model, a biphenyl analogue of macolacin proved to be effective against extensively drug-resistantwith colistin-resistance, thus providing a naturally inspired and easily produced therapeutic lead for overcoming colistin-resistant pathogens.
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