The findings in mice suggest a new therapeutic approach to treating Alzheimer's and other age-related diseases. Many neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by the presence of harmful protein clusters in the brain. Despite significant efforts to find way
Neurodegenerative diseases are conditions that affect the functioning of the brain and nervous system, leading to the progressive loss of structure or function of nerve cells. Some examples of neurodegenerative diseases include Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. These diseases can cause problems with memory, movement, and overall brain function, and they often get worse over time.
Kipnis is an expert in the blossoming field of neuroimmunology, the study of how the immune system affects the brain in health and disease. In 2015, he discovered a network of vessels that drains fluid, immune cells, and small molecules from the brain into the lymph nodes, where many immune system cells reside.
“Cerebrospinal fluid flow is impaired in numerous neurodegenerative diseases, such as Alzheimer’s, stroke, Parkinson’s, and multiple sclerosis,” Drieu said. “If we can restore fluid flow through the brain just by boosting these macrophages, maybe we can slow the progression of these diseases. It’s a dream, but who knows? It might work.”
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