Named MK-0616, the drug led to a considerable decline in study participants' LDL cholesterol levels.
Phase 2 trial of MK-0616, a new experimental drug, shows promise for addressing the high LDL cholesterol levels by reducing "bad" cholesterol levels by 60 percent in eight weeks.The new pill inhibits the activity of a specific protein called PCSK9, which can decrease the amount of LDL cholesterol the liver breaks down.
The clinical trial included 381 adults with either a history of heart disease or risk factors for heart disease and high levels of LDL cholesterol. At the beginning of the study, around 60 percent of the participants were already on statins, while approximately 25 percent were being treated with high-intensity statin therapy.
Crucially, no harmful side effects at any of the dosages were observed or reported by the research team who are seeking further trials to investigate MK-0616 in more detail. Objectives: This Phase 2b, randomized, double-blind, placebo-controlled, multi-center trial aimed to evaluate the efficacy and safety of MK-0616 in participants with hypercholesterolemia.
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