'There are a lot of conditions under which women are at increased risk for depression compared with men'
from Mathematica, a social policy research firm. Despite this, many women struggling with postpartum depression do not receive any treatment, and the current standard of care—antidepressants and psychotherapy—can be time-consuming and inaccessible for many mothers with newborns, and do not always eliminate women’s symptoms.
Zuranolone works similarly to its predecessor—both target the GABA receptors in users’ brains, which are believed to affect stress. But the new drug has several potential benefits compared to the existing medication. Brexanolone, which is administered intravenously over the course of 60 hours and sold under the brand name Zulresso, costs $34,000 without insurance. Its administration requires an often expensive two-and-a-half day stay at a health care facility, and few hospitals carry it.
Although there has been significant research into the underlying mechanisms that cause postpartum depression in recent years, a historic lack of research into women—especially those who are pregnant or breastfeeding—has held back the advancement of new treatments, experts say.
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