Urgent research to bolster disease defences demands equitable responsibility and ownership between partners.
Lumefantrine is an established drug that is often used in combination with another antimalarial called artemether. But growing resistance of the malaria parasite to artemether has accelerated the hunt for a new partner for lumefantrine. “We have to think about what the alternative drug will be,” says WANECAM member Rella Zoleko Manego, a medical doctor who is running the clinical trials in Gabon at the Centre de Recherches Médicales de Lambaréné .
In September 2021, MMV and Novartis reported positive results from a separate clinical trial carried out in India and six African countries, which indicate that the ganaplacide/lumefantrine drug combination has the potential not only to clear malaria infection, including resistant strains, but could also block the transmission of the malaria parasite.
Another major factor in ensuring an equitable partnership, Sutherland says, is that much of the responsibility for managing the project’s budget lies with the African researchers. Sutherland has been involved in scientist training programmes in Africa for 20 years, and says it is significant that WANECAM also runs workshops that focus on building bureaucratic capacity, such as training local finance managers and project administrators.
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