The trial, believed to be the first of its kind, was small, and the effect was far from dramatic.
At one point at the beginning of the pandemic, there was hope that a popular and inexpensive over-the-counter heartburn drug might hold promise for treating Covid-19, but a newly published study shows mixed results.
In the clinical trial, people with mild to moderate Covid-19 who took very high doses of famotidine, the active ingredient in Pepcid, had some improvement in their symptoms more quickly than those who took a placebo, a pill that does nothing. But the trial, believed to be the first of its kind, was small, and the effect was far from dramatic. Among the 55 study participants, those who were assigned to take famotidine had an estimated 50% reduction in symptoms at 8.
Dr. Paul Offit pointed to findings in the new study that examined inflammation markers in the blood of 35 of the participants. Those results showed that the people on famotidine had their inflammation resolve more quickly than those on placebo. The NIH recommends using tocilizumab, an arthritis anti-inflammatory drug, to treat hospitalized Covid patients.
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