Alcohol, even moderate, may speed progression of Alzheimer's disease

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Alcohol, even moderate, may speed progression of Alzheimer's disease
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Drinking may increase the likelihood of not only Alzheimers disease, but other conditions, such as cardiovascular disease and Type 2 diabetes. alzassociation – via healthing_ca alcohol dementia

Hemsworth, best known for his role as Thor in the Marvel movies, has the APOE e4 gene, which increases the risk of developing Alzheimer's earlier in life.Although previous research suggests that alcohol use is a risk factor for Alzheimer’s, the effect of alcohol-use disorder on the pathology of the disease remains unclear. To explore the relationship, researchers used mouse models of Alzheimer’s disease-related pathology.

They found that the consumption of alcohol increased brain atrophy and increased the presence of amyloid plaques — including a larger number of smaller plaques — a development that may set the stage for the increased production of such plaques later in life. They also found that the acute withdrawal from alcohol increased the presence of amyloid-beta, a key component of amyloid plaques that have been found in Alzheimer’s patients.

They also discovered that chronic exposure to alcohol led to a poorly regulated brain and peripheral metabolism — another way in which the substance may accelerate the progression of the disease. Even moderate drinking led to elevations in blood sugar and markers of insulin resistance that increases the likelihood of not just Alzheimer’s disease, but other conditions, such as cardiovascular disease and Type 2 diabetes.

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