CAPITAL: A major advance in single-cell RNA data analysis osaka_univ NatureComms
, and the representative cell in each cluster is defined as a virtual cell with the median measured in the reduced dimensional space, which is called a. Respective trajectories are computed by finding the minimum spanning trees in the centroid-based graphs. Tree alignment of the centroids across different datasets is performed by a dynamic programming algorithm .
CAPITAL has an assumption that it can deal with a pair of single-cell trajectories with any number of branches , but not cycles and disconnected graphs. Note that any pair of input trajectory trees can be accepted regardless of how similar they are in theory, but the comparison of datasets from completely different cell populations that are expected to have trajectories with different shapes is not relevant in practice.
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