Diabetes drugs that also promote weight loss, such as Novo Nordisk’s Ozempic, are being studied to tackle some of the most difficult-to-treat brain disorders, including Alzheimers disease.
LONDON - Diabetes drugs that also promote weight loss such as Novo Nordisk’s Ozempic, becoming a darling of celebrities and investors, are being studied to tackle some of the most difficult-to-treat brain disorders, including Alzheimer’s disease.
Several scientists interviewed by Reuters pointed to mounting research supporting testing diabetes drugs against neurodegenerative diseases. Dr. Suzanne Craft, professor of gerontology and geriatric medicine at Wake Forest University School of Medicine, gave a keynote speech at an influential Alzheimer's scientific meeting late last year about the need to test treatments such as diabetes drugs to further reduce the advance of Alzheimer's.
"This is what these agents do, and what insulin does. It plays a role in regeneration. And that's what needs to happen. Given its role in modulating immune function, it may prevent the amyloid from continuing to accumulate," Craft surmised. Ivan Koychev, consultant neuropsychiatrist for Oxford University Hospitals NHS Foundation Trust, is running a trial testing semaglutide with the aim of halting the earliest changes in the brains of people at risk of developing Alzheimer's.
Parkinson's trials tend to take less time and may require fewer patients because it's easier to assess the impact on motor function characteristics of the disease to understand whether the treatments benefit the brain.
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