Anxiety Relief in Sight: Scientists Identify Key Gene — An international group of re |
Scientists from the Universities of Bristol and Exeter have identified a gene in the brain that drives anxiety symptoms and demonstrated that modifying this gene can significantly reduce anxiety levels, presenting a potential new target for anxiety treatment.
An international team of scientists has identified a gene in the brain that is responsible for symptoms of anxiety. Significantly, altering this gene has been demonstrated to decrease anxiety levels, presenting a promising new avenue for drug treatment targeting anxiety disorders.
In this study, scientists sought to identify the molecular events in the brain that underpin anxiety. They focused on a group of molecules, known as miRNAs in animal models. This important group of molecules, also found in the human brain, regulates multiple target proteins controlling the cellular processes in the amygdala.
The discovery of a novel amygdala miR483-5p/Pgap2 pathway through which the brain regulates its response to stress is the first stepping stone towards the discovery of novel, more potent, and much-needed treatments for anxiety disorders that will enhance this pathway.
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