The experiments are a significant 'proof of concept' for the new therapy, which could also be used on humans in the future.
Researchers have successfully eradicated deadly pneumonia infections from the lungs of mice by pouring armies of swimming microbots down the rodents' windpipes. The unorthodox treatment, which directly targets the site of the infection, was 100% effective at curing infected mice and if follow-up studies show it also works in humans, could one day be used in people.
The experiments are a significant"proof of concept" for the new therapy, which could also be used on humans in the future, researchers wrote in a new paper published online Sept. 22 in the journal Nature Materials . By comparison, injecting microbots through the windpipe — whereupon the algae's swimming ability naturally spreads them throughout the rest of the lungs — means that the antibiotics are accurately and quickly delivered to the site of the infection almost immediately. During IV injections, a large proportion of the antibiotics can also end up going to waste, which can reduce the effectiveness of treatments.
During extreme cases of pneumonia, patients are often placed on ventilators to help them breathe. This means that many critically ill patients will already have tubes leading directly into their lungs, which could be used to deliver microbots, the researchers noted. The key to the microbots' anti-inflammatory effect is the nanoparticles that are stuck onto the microalgae. The antibiotic-containing capsules are covered in the cell membranes of neutrophils, a type of white blood cell that is part of the body's natural immune response.
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