Bacterial enzyme makes new type of biodegradable polymer

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Bacterial enzyme makes new type of biodegradable polymer
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Strings of sugars called polysaccharides are the most abundant biopolymers on Earth. Because of their versatile and environmentally friendly properties, these molecules could eventually replace some plastics. Now, researchers reporting in ACS Central Science have identified a previously unknown bacterial enzyme that can make a new type of polysaccharide, which is similar to the biopolymer chitin. The new molecule is biodegradable and could be useful for drug delivery, tissue engineering and other biomedical applications.

A bacterial enzyme makes a new type of biodegradable polymer, acholetin, which might someday find use in drug delivery, tissue engineering or other applications. Credit: Adapted fromStrings of sugars called polysaccharides are the most abundant biopolymers on Earth. Because of their versatile and environmentally friendly properties, these molecules could eventually replace some plastics.

Polysaccharides play many roles in organisms, and because they are biocompatible and biodegradable, these molecules are promising carrier materials for a broad range of therapeutics. The identity of individual sugar molecules in the chain, and the way they are linked together, make them function in different ways. Enzymes known as glycoside phosphorylases can cut certainapart or make new ones, depending on the reaction conditions.

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