Dr F. Perry Wilson reviews a study suggesting that what we thought was a purely random disease might actually be an infectious one.
Most of the textbooks continue to describe CAA as a sporadic condition, but there have been some intriguing studies that suggest it may be transmissible.highlights cases that seemed to develop after the administration of cadaveric pituitary hormone.
So that's exactly what the researchers, led by Jingchen Zhao at Karolinska University, did. They identified roughly 760,000 individuals in Sweden and 330,000 people in Denmark who had received a blood transfusion between 1970 and 2017. The big question: Would recipients who got blood from individuals who later on had brain bleeds, have brain bleeds themselves?
I know what you're thinking. What's the agent? What's the microbe, or virus, or prion, or toxin? The study gives us no insight there. These nationwide databases are awesome but they can only do so much. Due to the vagaries of medical coding and the difficulty of making the CAA diagnosis, the authors are using brain bleeds as a proxy here; we don't even know for sure whether these were CAA-associated brain bleeds.
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