Beyond the Chemical Imbalance Theory of Depression

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Beyond the Chemical Imbalance Theory of Depression
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A psychiatrist’s lonely battle to dismantle a broken system

In 2022, a large review led by Joanna Moncrieff showed the ‘serotonin theory of depression’ to be groundless.one in 5I talked with Prof. Moncrieff about her history of advocacy, the future of mental health, and a report that rattled the medical establishment.Last year, you co-authored an umbrella review showing that there’s simply no compelling evidence for the serotonin theory of depression.

I guess none of that was really a surprise, but the level of defensiveness was extraordinary, and the fact that the profession found it quite impossible to be honest with people, that actually these results have major implications for how we think about antidepressants and whether you should be using them.Let me go right to antidepressants, because that's an obvious motive behind the criticisms.

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