Biology: New immune-evading COVID variants could fuel surge

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Biology: New immune-evading COVID variants could fuel surge
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New Omnicron strain XBB.1.5 shows COVID virus is still evolving. Understanding why virus has changed, and what it means for the future can be helpful.

Like all living things, the virus that causes COVID-19 continues to evolve, illustrating why we need to understand the forces of evolution.

If the single-stranded genetic structure of SARS-CoV-2 is loosey-goosey, its reproductivebehavior is even worse. As a dual-infected host cell cranks out copies of both viruses, it can include genes from both parent lineages in newly produced viruses. Some of those recombinant viruses succeed well relative to other SARS-CoV-2 variants in their environment. The omicron subvariant XBB appeared through this recombination process last year.

As of one week ago, the XBB.1.5 subvariant caused half of all new COVID-19 cases in theUnited States. It caused over 85% of new cases in the Northeast, and it caused 24% of new cases in the Midwest, including Ohio. The XBB.1.5 subvariant likely will continue to increase its contribution to new COVID-19 infections in the United States.

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