So now we need improved treatment for overweight people.🧐
University of Southampton published on Tuesday. Researchers from the institution found that patients with a high body mass index had an environment around their breasts that could lead to the growth of tumors in that area.More specifically, the researchers discovered that increased body fat surrounding the breast can cause inflammatory immune cells, called macrophages, to collect and accumulate in the breast's fat tissue.
To reach this conclusion, the researchers assessed samples from a group of HER2+ breast cancer patients and examined the link between high body mass index and the development of crown-like structures. They concluded patients who were overweight or obese had significantly more crown-like structures in the fat tissue surrounding their tumors and they were more prone to faster development of metastatic disease.
They even pinpointed a potential molecular biomarker called CD32B that when found on the surface of the macrophages in these crown-like structures resulted in a decreased response to therapy.
Beers continued,"On the other hand, this study highlights how effective trastuzumab treatment is in patients that do not have the marker. So these patients could benefit from a lower dose of anti-HER2 therapy which may minimize the side effects they experience. Further studies with more patients will be needed to help confirm these initial findings."
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