Cancer cells delete DNA when they go to the dark side, so a team of doctors and engineers targeted the 'backup plans' that run essential cell functions. Researchers at the University of Michigan and Indiana University have discovered a cancer weakness. They found that the way that tumor cells ena
have discovered a cancer weakness. They found that the way that tumor cells enable their uncontrolled growth is also a weakness that can be harnessed to treat cancer.
Abhinav Achreja, Ph.D., Research Fellow at the University of Michigan Biomedical Engineering and Deepak Nagrath, Ph.D. Associate Professor of Biomedical Engineering work on ovarian cancer cell research in the bio-engineering lab at the North Campus Research Center . Credit: Marcin Szczepanski/Lead Multimedia Storyteller, University of Michigan College of Engineering
In doing so, the cells typically lose other genes that are necessary for survival. To avoid death, the cells find a paralog—a gene that can serve a similar function. Usually, there are one or, possibly, two genes that can step in and perform the same function to keep the cell alive. Attacking metabolic pathways essentially shuts down the cell’s energy source. In examining ovarian cancer cells, U-M’s team zeroed in on one gene, UQCR11, that was often deleted along with a suppressor gene. UQCR11 plays a vital role in cell respiration—how cells break down glucose for energy in order to survive.
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