Researchers discover differences in DNA methylation inside brain region important for inhibitory control in people with cocaine use disorder. Scientists tend to view substance addiction as primarily a disease of the brain. When we enjoy sex, food, music, or hobbies, regions of our brain within th
Cocaine use disorder causes alterations in the “methylome” of Brodmann Area 9, a subregion within the prefrontal cortex, which is responsible for self-awareness and inhibitory control. This is according to a study conducted by researchers from Germany and Canada and published in. An increased level of DNA methylation is associated with the suppression of neighboring genes.methylation inside brain region important for inhibitory control in people with cocaine use disorder.
“As DNA methylation is an important regulatory mechanism for gene expression, the identified DNA methylation alterations might contribute to functional changes in the human brain and thereby to the associated behavioral aspects of addiction,” said first author Eric Poisel, a PhD student at the Central Institute of Mental Health in Mannheim, Germany.
“As biological age estimation is a very recent concept in addiction research and is influenced by many factors, further studies are required to investigate this phenomenon, with larger sample sizes than were possible here.”Poisel and colleagues also looked at differences in the degree of methylation at 654,448 sites in the human genome, and looked for associations with the presence or absence of CUD in the life of each donor.
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