New data gives more evidence to the possibility that developing a pathobiome in the brain could cause some forms of Alzheimer's and related dementias.
to enter the brain. In Alzheimer's brain samples, the researchers noted, these pathogenic bacteria appeared to have overpowered and replaced"Perhaps destruction of theGarth D. Ehrlich, PhD
, an adjunct associate professor in the College of Medicine, and a senior author of the study."Perhaps plaques, whose constituents have anti-microbial properties in vitro, aren't the direct cause of Alzheimer's, but instead are a response to bacteria in the brain -- some benign, some pathogenic, perhaps causing damage that has not yet resulted in cognitive deficits, making them part of the pathobiome.
"The development of Alzheimer's and other dementias is complex and likely involves the interaction of many systems," said Ehrlich."I'm a believer in the more infections you get in the brain, the higher your risk of Alzheimer's. There are many pathogens that likely increase the risk. This pathobiome is not the whole answer, but it's a piece of the puzzle."
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