Covid-19 Vaccine Efficacy: What Do the Numbers Really Mean?

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Covid-19 Vaccine Efficacy: What Do the Numbers Really Mean?
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Do Covid-19 vaccines prevent infection? Do they protect against severe disease and hospitalization? Here’s what we know about how the shots perform against the Delta variant via WSJ

John Moore, an immunologist at Weill Cornell Medical College in New York, said studies don’t find the sameconditions such as time periods or geographies. “It’s hard to know where the percentage of efficacy drop is because they vary in studies, and have different circumstances, and putting a single number on them is tricky,” he said.

vaccinated people aren’t surprising because the vaccines aren’t entirely protective and vaccinated people have interacted with other people more frequently, making exposure to the virus more likely. “What we’re seeing is more infections among vaccinated people,” she said. “We always expected that.”of the Delta variant combined with the likelihood that immunity from vaccines is declining over time, Dr. Moore said.

More recent studies also show drops in effectiveness against symptomatic illness, including a preprint study from August by researchers at the University of Oxford that found that the Pfizer and AstraZeneca vaccines’More symptomatic infections and declining vaccine effectiveness are likely a reflection of the vaccine’s strength dropping as well as the high rate of spread of the Delta variant, said Saad Omer, a virologist and director of the Yale Institute for Global Health.

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