A preprint study found that nearly a third of people with Covid experienced rebound symptoms and 12% tested positive again, regardless of whether they'd taken Paxlovid.
A health worker places a test swab into solution for a PCR Covid-19 test in Hawthorne, Calif., on Jan. 18, 2022.Reynolds Lewis
Around a third of people with Covid will experience a rebound of their symptoms, regardless of whether they’ve been treated with the antiviral Paxlovid, according to aThe preprint study — meaning it hasn’t been published in a peer-reviewed journal — found that 27% of people with Covid saw a rebound in their symptoms after they had initially improved.“It happens all the time. People who are untreated with Covid who then feel better can get symptoms afterward,” said study co-author Dr.
The study also found that 12% of people with Covid had a “viral rebound,” meaning they tested positive again several days after testing negative. This has been documented among people who have taken Paxlovid and is referred to as, but the study found that viral rebound occurred regardless of whether a person had taken the antiviral treatment.
Anyone who has had Covid could see a return of symptoms after they’ve initially gone away, and those symptoms could be worse or not as bad as the first bout, Smith said. “It’s just the variability in the natural course of the infection.” The Centers for Disease Control and Prevention has acknowledged the possibility of symptom recurrence in untreated Covid patients. When the agency in May issued ainforming physicians about Paxlovid rebounds, it also said that “a brief return of symptoms may be part of the natural history of SARS-CoV-2 infection in some persons, independent of treatment with Paxlovid and regardless of vaccination status.”“In some ways, that’s the natural history of all respiratory viral infections,” said Dr.
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