It is estimated 62,900 people in Wales had Covid in the week ending 20 September.
It has become the most important tool to measure the level of infections, with the end of mass testing at the end of March.
The ONS estimated infections to involve one in 65 people in England, one in 45 in Scotland and one in 58 in Northern Ireland.Meanwhile, the so-called R-number - the reproduction number - has risen for the first time in more than a month.The range remained between 0.7 to 1.1 throughout August and most of September but has now risen slightly to between 0.8 and 1.2, suggesting for every 10 people with Covid in Wales, between another eight and 12 people would be infected.
Only an average of 11 patients across Welsh acute hospitals have been primarily treated for Covid in the past week. The number of patients testing positive for Covid in hospital beds in Wales averaged 305 a day in the last week of September - up 40% on the previous week, according to the Digital Health and Care Wales figures.
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