The study examined the impact of celecoxib and indomethacin, two types of non-steroidal anti-inflammatory drugs (NSAIDs) classified by the World Health Organization (WHO) as the initial level of pain relief medication, along with paracetamol. According to a study conducted by the University of Sã
Dental enamel defects are abnormalities that affect the structure and integrity of the enamel, the hard, protective outer layer of the teeth. These defects can be congenital or acquired and can have a significant impact on the health and appearance of the teeth.
The study, conducted by researchers from the Ribeirão Preto Dental School and School of Pharmaceutical Sciences at the University of São Paulo, examined the impact of celecoxib and indomethacin, non-steroidal anti-inflammatory drugs classified by the World Health Organization as the initial step on the analgesic ladder, in addition to paracetamol.
A coincidence aroused the researchers’ curiosity most of all: the patients’ ages. The first years of life, when DEDs form, are a period in which sickness is frequent, often with high fever.
When the researchers looked for the reasons for this, they found alterations in proteins required for the mineralization and cellular differentiation, showing that the drugs had indeed affected the composition of the dental enamel.“Right now, the study at least offers us a clue to the identity of a new player that may be involved in the development of DEDs. Hitherto we’ve been totally in the dark,” said Paula-Silva.
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