Mixing and matching various strands of DNA can create versatile biological computer circuits that can take the square roots of numbers or solve quadratic equations
into larger structures that could serve as circuit components, like wires, or function to direct those wires to form different configurations.
They put this into practice by filling tubes with DNA strands and a buffer fluid and letting them attach to each other, combining into larger molecules through chemical reactions. The researchers also equipped all the molecules with fluorescence markers so they could keep track of what the circuit was doing based on how its parts were glowing.Sign up to newslettercould be designed to implement over 100 billion distinct circuits by adding different short molecules into its tube.
In one experiment, they connected three DPGAs, comprising about 500 DNA strands, to make a circuit that solves quadratic equations, and in another, they made a circuit for taking square roots. They input numbers by adding molecules of a specific shape that then participated in chemical reactions with molecules that made up the circuit, analogous to an electron moving through wires.
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