RT mnt: Do antidepressants work better than placebo? mnt depression antidepressants
Scientists have been debating the efficacy of antidepressants for decades. The latest paper to throw its hat into the ring concludes that there is little evidence to show that they perform better than placebos.
Why the doubt? To a greater or lesser degree, all the factors below and more have combined to produce a situation where scientists are still not clear whether antidepressants work better than a placebo: They set out to"compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder," as a guide for doctors.
In it, the authors outline a number of issues. For instance, in an ideal study, participants are"blinded." This means that they do not know whether they are receiving the drug or the placebo. "Publication bias of antidepressant trials is pervasive and distorts the evidence base. Many industry funded antidepressant trials remain unpublished or are inadequately reported."
Also, effect sizes were relatively small, and although statistically significant, they may not be clinically significant.
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