Religious or spiritual experiences and psychedelics both seem to increase introspection and positive mood by acting on a few key brain regions. The relationship between the two may go back millennia.
Psychedelics and prayer both produce alterations of perceptions and mood, and both have anxiolytic, analgesic, and antidepressant properties.
Ayahuasca, DMT, psilocybin, LSD, and mescaline acutely activated the frontal cortex, temporal cortex, and cingulate gyrus. Psychedelics and prayer can both produce alterations of perceptions and mood, and both have been shown to have anxiolytic, analgesic, andproperties. A variety of different studies using functional magnetic resonance imaging have defined a group of brain structures and cortical regions that become active, or show evidence of induced neuroplasticity, with either exposure to a variety of psychedelics or intense spiritual experiences.
An analysis of multiple studies that utilized electroencephalography, fMRI, and PET investigated a wide range of religions, including Christianity, Buddhism, and Islam, while participants were resting or in prayer. These studies are often fraught with difficulties, such as having no appropriate control group, varying measures ofof each participant, and small sample sizes.
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