Post-menopausal women who are able to lose even a modest amount of weight — and keep it off — may reduce their risk of developing breast cancer, research published Tuesday finds
Other than skin cancer, breast cancer is the most commonly diagnosed cancer in women in the U.S. It's also the second deadliest cancer among women.estimates the average woman's risk for developing breast cancer is 1 in 8, or about 12 percent.
How postmenopausal obesity impacts breast cancer development is not well understood, but it appears to center on hormones. Fat cells make estrogen, which can, in turn, fuel some forms of breast cancer. Breast cancer experts also say certain other hormones and chronic, low-level inflammation may also play a role in the link between obesity and breast cancer."There are a lot of things that are different when you have excess body weight than when you don't," Ligibel told NBC News.
While some breast cancer risk is genetic, lifestyle factors can also contribute, such as lack of physical activity, alcohol intake and some forms of. In the new research, the link between weight loss and breast cancer risk was only observed in women who were not taking hormone replacement therapy, said Teras.
"A greater proportion of the women in this study used postmenopausal hormones than do today," she told NBC News. The number of women on hormone therapy has dropped significantly since the early 2000s, when research found that it was linked to an increased risk for heart problems.
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