A clinical trial comparing efficacy of Ecigarettes versus nicotine patches for smoking cessation in pregnant women revealed no differences between interventions. E-cigarettes showed some benefit only in women who adhered strictly to the trial protocol
Randomization and blinding
For the primary outcome we conducted three pre-specified sensitivity analyses: a per-protocol analysis that excluded participants who did not start product use or never established contact with the study team, an analysis in which we estimated missing data using multiple imputation by chained equation, and an analysis in which we excluded abstinent participants who used non-allocated products for at least 5 consecutive days during the 4 weeks after the TQD or who reported end of pregnancy...
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