Future therapies in multiple myeloma. MMSM
— cevostamab targets of FcRH5 — did have cohorts, around 20% here and there, that had prior BCMA therapy. I'd like to look at those data and see what it is. They are small numbers, but at least it helps us to understand beyond BCMA what we may do for these patients.It's really important as we go forward to understand BCMA resistance a little bit better. It seems you wouldn't go immediately from one CD38 to another. I think we've shown this pretty unequivocally.
MoDs?are a great way to try to target the myeloma cell, taking advantage of what the cell depends on, which is this intracellular signaling cascade. Ultimately, the garbage disposal of a cell has to function correctly. When that's disrupted, either by a proteasome inhibitor or more proximately some signaling cascade with
MoDs in a disease we've yet to cure. In a disease that can present in so many ways, from extremely aggressive to less aggressive, it's really nice to have different tools in the toolbox. MoDs — we have a chance to think about them not just as their own drug, but if they could be a good partner for the existing awesome immunotherapies like CAR T-cell therapies and bispecifics. My hope is to go into a steroid-free zone with combining all of these things because it tries to limit the drug that a lot of patients just hate.I agree with you.
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