As many as one in 500 men may carry an extra sex chromosome – either an X or a Y – but very few of them likely know about it, a new study suggests.
, included data from more than 207,000 men who provided information to the UK Biobank, a repository of genetic and health data from half a million UK-based participants.in each of their cells, but among the study participants, there were 213 men who carried an extra X chromosome and 143 that had an extra Y.
"We were surprised at how common this is," Dr. Ken Ong, a pediatric endocrinologist in the Medical Research Council Epidemiology Unit at the University of Cambridge and a co-senior author on the study,Previous estimates suggested that roughly 100 to 200 men out of every 100,000 are XXY, according to the
That's because UK Biobank volunteers tend to be healthier than the general population and have a lower-than-average incidence of genetic conditions. Based on this, the authors estimate that about one in 500 men, or 0.2 percent, in the general population carry an extra sex chromosome. For instance, Klinefelter syndrome – or having an extra X chromosome as a male – has been linked to reproductive problems, including infertility and delayed puberty, according to the National Human Genome Research Institute.
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