Science, Space and Technology News 2023
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“Previously, there have been studies on specific drug combinations, especially those commonly prescribed together in the clinic,” said Elisabetta Cacace, the first author of the study and former PhD student in the Typas group. “However, we lacked systematic knowledge of how combinations of different classes of antibiotics, or combinations of antibiotics and non-antibiotic drugs, influence bacterial physiology, especially when considered independently of the host.
For the current study, the team used a sophisticated robotics set-up to simultaneously study the effects of hundreds of combinations of antibiotic and non-antibiotic drugs, across a range of doses, on three representative species of Gram-positive bacteria –.
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