In our latest News and Views, Joel Ernst and Paul Ogongo discuss how single-cell, longitudinal analyses can help inform vaccine development for TB MakOgongo_3 UCSF
proteome includes nine other peptides in other PE proteins with >80% sequence similarity to this epitope, which prompts the question: might protection be a consequence of cross-recognition of multiple PE13-related proteins expressed by? CFP-10 is notable for its deletion from the existing BCG TB vaccine, and it is secreted as a heterodimer with ESAT-6, which is implicated invirulence. Thus, it stands to reason that CFP-10 would be a valuable vaccine antigen.
It is especially noteworthy that the authors identified an epitope recognized by T cell clonotypes enriched in TB progressors, potentially reflecting a ‘bad’ antigen. This epitope is from. The apparently opposite effects of T cell recognition of CFP-10 and EspA highlights the challenges of empirically choosing antigens and emphasizes the need for further systematic analyses incorporating T cell phenotypes, epitopes and TB outcomes.
The authors’ finding that a large majority of TCR similarity clusters are found with equal frequencies in TB controllers and TB progressors implies thatexpresses numerous antigens and epitopes that induce T cells with little impact on TB outcomes — and are therefore useless in the context of infection or vaccine responses.
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