During prostate cancer treatment, some gut bacteria start making hormones that may support cancer growth and treatment resistance, new research indicates.
This study is the first to show that bacteria can produce testosterone, although the investigators are not yet sure what triggers them to start doing that. Androgen deprivation treatment may also lead to more of these hormone-producing microbes in the gut, the results suggest. Fecal bacterial of people with treatment-resistant prostate cancer also showed a link to lower life expectancy.
Fecal transplants from mice with treatment-resistant prostate cancer could trigger resistance in animals with disease susceptible to these hormones. When these mice received fecal transplants from humans with resistant cancer, the effect was the same: a shift to treatment resistance. But the converse also was true: Fecal transplants from mice or humans with hormone-susceptible cancer contributed to limiting tumor growth.
The findings may suggest new therapeutic targets: the microbes living in the gut. In mouse studies, the researchers found that when they wiped out these bacteria, the cancer was much slower to progress to treatment resistance. Authors of a say there are other places to look for bacteria that might be making these hormones, too, including the urinary tract or even in the tumor itself.: “Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis,” “Gut bacteria enable prostate cancer growth.”
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