Brain scans of people with binge-eating disorder or bulimia show altered activity in areas linked to habit formation and hint at new possibilities for eating-disorder treatments.
The putamen has been associated with habit formation, following brain scans of women with binge-eating disorder or bulimia.Brain scans of people with binge-eating disorder or bulimia show altered activity in areas linked to habit formation and hint at new possibilities for eating-disorder treatmentsA habitual behaviour is automatically triggered by external cues — for example, reaching for the seat belt as soon as you get into the car.
Functional magnetic resonance imaging uncovered changes in these areas in people with eating disorders, compared with those without them. The imaging showed alterations in the structure of the grey matter and in dopamine signalling in the sensorimotor putamen in particular.
“This study adds pretty nicely to some mounting evidence suggesting that brain circuitry that involves the putamen is likely implicated in binge-eating behaviour,” says psychiatrist Laura Berner at the Icahn School of Medicine at Mount Sinai in New York City. Dopamine is a a neurotransmitter released in response to reward, and the researchers expected the brains of people with eating disorder to show the effects of repeated exposure to reward. The putamen seemed to have fewer receptors for dopamine than did healthy brains, and the researchers suspect that increased release of dopamine might dial down the sensitivity of the dopamine receptors and reduce their number.
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