To raise awareness of StemCellAwarenessDay, here is a study investigating HSCT chemotherapy in causing microglia senescence and peripheral macrophage engraftment in the brain
, blue open arrowhead). Scale bar=20 μm. Plot of host macrophage density at control , 1 day , 1, 2, 4, 6, 12 and 24 weeks post-HSCT . Plot of donor macrophage density vs. host microglia density at 12 and 24 weeks post-HSCT. . Macrophage convex hull plot at 12 and 24 weeks post-HSCT . Convex hull plot of donor and host parenchymal macrophages .cells . Scale bar=100 μm. Plot of Ki67density in subventricular zone of the lateral ventricles .
Confocal images of NG2 immunohistochemistry of dorsal cortex in control , 4 and 24 weeks post-HSCT with NG2cell density at control , 1 day, 1, 2, 4, 6, 12 and 24 weeks post-HSCT . Tiled brain hemispheres at Control, 2, 4, 6, 12 and 24 weeks post-HSCT of NG2 cells. Control brain section has dense labeling of NG2 cells throughout cortex. Two weeks post-HSCT most NG2 cells are lost in cortex but small population of dense labeled NG2 cells found in thalamic regions .
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