“It’s a really nice survey of the mammals that are out there.”
An international team of more than 100 researchers has
Those spots, which have remained mostly unchanged across some 100 million years of evolution, may be parts of the genomes that are “doing something important,” geneticist Elinor Karlsson of the Broad Institute of MIT and Harvard and the University of Massachusetts Chan Medical School in Worcester said in an April 25 news briefing. Sections with lots of changes are interesting too, she says, and can offer clues about how a particular species may be adapting to its environment.
Balto most likely had an enhanced ability to digest starch and carried relatively few potentially damaging mutations, the researchers report. He was also less inbred than modern dogs — a sign that his population was genetically healthy. So a cancer mutation in these areas “is probably one of the ones to focus on,” says Gallego Romero, who wrote. It could be one of the key genetic changes responsible for setting off the disease, she says. Homing in on these potentially problematic mutations could help scientists identify suspicious genes and figure out treatments.Scientists have known for decades that some stretches of organisms’ genomes can hop from one location to another.
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