High-sugar diet disrupts the gut microbiome, leading to obesity (in mice)

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High-sugar diet disrupts the gut microbiome, leading to obesity (in mice)
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Sugar drives the overgrowth of specific bacteria.

Sugar may disrupt the community of bacteria living in the gut, thereby depleting crucial immune cells and causing obesity down the line, a new mouse study suggests.

This, in turn, caused the mice to become obese and develop features of"metabolic syndrome," a cluster of conditions — such as high blood pressure, high blood sugar and insulin resistance — that collectively raise the risk of heart disease, stroke and type 2 diabetes.

In their recent mouse study, the researchers placed mice on a high-sugar, high-fat diet for a month to see how their gut bugs might change. They found that the diet spurred the growth of a bacterium called Faecalibaculum rodentium, which essentially crowded out the SFB growing in the mouse gut, depleting its numbers.

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