In spring 2022, more people than expected were dying from all causes in many states, but not in highly-vaccinated Massachusetts.
"We'd boosted many high-risk people in fall 2021, before Omicron swept through the state. So by spring 2022, the state's high vaccination rate, and the immunity from recent infections, limited the disease's ability to spread ," Faust said.accompanied COVID-19 outbreaks in Massachusetts, according to the CDC.
Despite these factors, all-cause mortality during this period was similar to pre-pandemic rates. Only 0.1 excess deaths per 100,000 person-weeks occurred — 134 excess deaths statewide — a statistically nonsignificant change . "All-cause mortality is one of the most unbiased ways to analyze the effects of the pandemic," Faust explained."Death certificates can over- or under-count COVID deaths, but all-cause mortality does not depend on cause-of-death determinations. So excess all-cause mortality tells us that, for sure, the overall situation is bad. Lack of excess mortality tells us that the situation is improving somewhat.
"Instead of reporting COVID deaths , we determined how many people would be expected to die during that time period, then we compared that number with how many actually died," he said.William Schaffner, MD, professor of preventive medicine in the Department of Health Policy, at Vanderbilt University Medical Center in Nashville, Tennessee, called this"a solid study" that reinforces data in the literature that show that COVID-19 vaccine protects against severe disease.
"The difference between the observed and expected all-cause mortality that was noticeable even during the initial Omicron wave is consistent with the pandemic's movement from the acute phase into the endemic phase," she said."Duration and strength of immunity, as well as impact of inevitable new variants, remain uncertain," Krauland cautioned."Clinicians still need to consider COVID-19 to be dangerous for their sickest patients.
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