An increase was observed even in individuals who used it for a short term around the age of menopause; despite the unclear causal connection, it is imperative to explore these findings more extensively in future studies. Menopausal hormone therapy could be linked to a higher risk of dementia and
New research suggests that the use of menopausal hormone therapy is linked to a heightened risk of dementia and Alzheimer’s disease. Although the study’s findings shouldn’t be taken as a direct causal relationship, it calls for further research on the topic.
Menopausal hormone therapy is used to relieve common menopausal symptoms such as hot flashes and night sweats. Treatments include tablets containing estrogen only, or a combination of estrogen and progestogen, as well as skin patches, gels, and creams. Drawing on national registry data, they identified 5,589 cases of dementia and 55,890 age-matched dementia-free controls between 2000 and 2018 from a population of all Danish women aged 50-60 years in 2000 with no history of dementia and no underlying reason preventing them from using menopausal hormone therapy.
Rates were higher with longer use, ranging from 21% for one year or less to 74% for more than 12 years of use.The use of progestin-only therapy and vaginal estrogen only was not associated with the development of dementia.
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