A new study finds that erectile dysfunction medications may aid in the treatment of esophageal cancer According to a recent study supported by Cancer Research UK and the Medical Research Council, a category of drugs often used to treat erectile dysfunction may be able to improve the effectiveness o
The research showed that chemotherapy combined with the erectile dysfunction drugs known as PDE5i shrunk the tumors more than chemotherapy alone.
Although it is a relatively uncommon condition, the UK has one of the highest rates in the world, with 9,300 new instances of esophageal cancer diagnosed there each year. Esophageal cancer affects the food pipe that links your mouth to your stomach. Following this, the researchers tested a PDE5 inhibitor, PDE5i, on CAFs from esophageal tumors. They found that PDE5i were able to suppress CAF activity and make them look more like normal fibroblasts.took samples of tumor cells from 15 tissue biopsies from eight patients and used them to create lab-grown artificial tumors. They tested a combination of PDE5i and standard chemotherapy on the tumors.
With the proven safety of these drugs and the positive results from this research, the researchers’ next step is a phase I/II clinical trial testing a PDE5 inhibitor in combination with chemotherapy in patients with advanced esophageal cancer.
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