Researchers at the Center for Genomic Regulation (CRG) have discovered how proteins work in tandem to regulate 'treadmilling,' a mechanism used by the network of microtubules inside cells to ensure proper cell division. The findings are published in the Journal of Cell Biology.
Three proteins were found to be critical for regulating treadmilling: KIF2A, abelonging to a larger family of proteins that dismantles microtubules, the γ-tubulin ring complex , a scaffold for microtubules to grow from, and spastin, an enzyme that acts like a scissor cutting microtubules.
"The family of proteins that dismantle microtubules usually nibble on microtubules at both ends. We were surprised to find that one member of this family—KIF2A—has a strong preference for minus ends. This specialization is exactly what researchers have been looking for to explain why microtubules treadmill in the spindle," explains Dr. Thomas Surrey, senior author of the study and researcher at the Center for Genomic Regulation.
Before KIF2A can nibble a minus end, it needs to overcome yTuRC, which acts like a safety cap."The enzyme spastin is required to freefrom the safety cap so that KIF2A can do its job once microtubule plus ends have grown long enough," explains Dr. Cláudia Brito, co-first author of the study. The researchers found that the correct control of treadmilling requires the coordinated action of all three proteins. While the study does not directly translate into therapeutic avenues, it adds another piece to the intricate puzzle of cellular function and division.which must develop into many trillions of cells, all containing good copies of the genome.
México Últimas Noticias, México Titulares
Similar News:También puedes leer noticias similares a ésta que hemos recopilado de otras fuentes de noticias.
Kelce center of attention in offseason, center of Eagles run to Super Bowl this seasonJason Kelce has mixed fun and football like no one else for the Philadelphia Eagles. Kelce is a Super Bowl champion and enters the season having started 139 straight games.
Leer más »
Kelce center of attention in offseason, center of Eagles run to Super Bowl this seasonJason Kelce has mixed fun and football like no one else for the Philadelphia Eagles
Leer más »
Evanston launches initiative to combat opioid overdosesBoxes with Naloxone, also known as Narcan, have been placed at the Evanston Main Library, Robert Crown Community Center, Evanston Ecology Center, Levy Senior Center and Fleetwood-Jourdain Community Center in a partnership with the city’s public library and parks and recreation department.
Leer más »
Researchers use 'topological gardening' to achieve unexpected spin transport'Trimming' the edge-states of a topological insulator yields a new class of material featuring unconventional 'two-way' edge transport, as reported in a new theoretical study from Monash University, Australia, published in Materials Today Physics.
Leer más »
Researchers reveal van Hove singularity at Fermi level in kagome superconductorA team led by Prof. He Junfeng from University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS), in collaboration with Academician Gao Hongjun's team from CAS and other domestic and international research teams, has discovered the van Hove singularity (VHS) at Fermi level in kagome superconductors and revealed its relationship with superconductivity. Their work was published in Nature Communications on June 28.
Leer más »
Building a stronger industry image will boost hospitality employment, say researchersFlinders University's Dr. Ashokkumar Manoharan collaborated with Associate Professor Christina Scott-Young (RMIT University, Melbourne), and Professor Anthony McDonnell (Cork University Business School, Ireland) to create a framework that creates an effective industry brand.
Leer más »