Northwestern Medicine investigators have uncovered new mechanisms by which iron deficiency inhibits cell growth and proliferation in eukaryotic cells, according to findings published in Nature Cell Biology.
and increases the anabolic processes inside the cell," said Ardehali, who is also professor of Medicine in the Division of Cardiology, of Pharmacology and director of the Center for Molecular Cardiology.
In the current study, the team analyzed different types of iron-deficient eukaryotic cells as well as livers from mice fed an iron-deficient diet. In doing so, they identified genome-wide changes to histone methylation—aSpecifically, they found that KDM3B, an iron-binding enzyme, acts as an iron sensor and inhibits mTOR activity through histone demethylation.
According to the investigators, the findings suggest that reducing anabolism by reducing iron could be a potential treatment strategy for cancer, which relies on anabolism to grow and spread., that can have synergistic effects in inhibiting cancer growth in addition to other chemotherapy agents.
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