An inhaled version of the drug is approved for severe depression. Many clinics, however, offer injections or infusions for a range of mental health conditions.
a version called esketamine, or Spravato, in 2019. It’s an inhaled version that must be administered in a doctor’s office, and it is approved only for people for whom other treatments have failed.
It’s unclear how ketamine works precisely in the brain. Dow said he believes it may boost feel-good chemicals, similar to traditional antidepressants, as well as reduce inflammation, and form new neural pathways that are associated with the ability to create new habits and behaviors.that can feel spiritual, which in itself can boost their mood, Dow said.
“The concern with these clinics’ popping up is that people are getting treatments that haven’t been well-proven, well-studied or following any guidelines,” said Dr. Smita Das, an associate professor at Stanford University School of Medicine and chairwoman of the American Psychiatric Association’s Council on Addiction Psychiatry. “My concern is that people who need treatment will spend their money and energy in these ketamine clinics that aren’t well-proven.
Das and Dow say they’re also concerned that some clinics may be offering the drug without any supervision, which is especially worrying if a patient has a “bad trip.”treatment-resistant depression“People can rarely experience paranoia or suicidal ideation,” Das said. “And so many of these clinics don’t have mental health professionals staffing them. When those mental health concerns pop up, they may not be equipped to respond appropriately.
Lynette Ebberts, 66, said that for her, ketamine was a lifeline. For nearly 40 years, she said, she tried dozens of combinations of antidepressants, electroconvulsive therapy and other treatments for her severe depression, but nothing worked. Ebberts said each 45-minute infusion felt like a dream, in which she saw vibrant colors and shapes. After she underwent three treatments in one week, she said, something started to shift.
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