New insight into how xerodermapigmentosum causative gene products ensure the accuracy of DNA repair nature
, light grey) shows the bent DNA associated with XPB and different position of XPD in the U-shaped Core7. Superposition of HD2 of four SF helicases, XPB, Rad26 , Snf2 and NS3 reveals that the tracking strands superimpose well in all cases.
The U-shaped Core7 in C7CD. The N-terminal helices of p44 that contact XPB are outlined in a rounded rectangle. The XPD and XPB arm are well separated. The σ-shaped Core7 in C7CAD with p34 superimposed to C7CD and viewed in the same orientation as in panel a. The interface at p34-p44 and p34-p52 remain unchanged. The stable interfaces of p34 with p44-RING finger and p52. The C-terminal p34-DZF and p44-ZR domain are labeled. A β hairpin of p34-DZF in C7CD is changed to a short α helix in C7CAD.
Two MutS DRDs are shown on the left side for comparison. Five DRD domains in TFIIH are shown after superposition with MutS DRDs. Each DRD is colored in rainbow fashion from the blue N- to red C-terminus. Four β strands are labeled 1 to 4, and strands 2 and 4 are each followed by an α helix . In the P52-p8 heterodimer, the two subunits complement each other by supply the partner DRD with the first β strand .
Sequence of three Cy5 DNA substrates, each of which contains a total 94 bp but different upstream and downstream length from Cy5 . Diagrams of the three DNA substrates. Dual incision results of each DNA substrate after incubation with Core7, XPC, XPA, RPA, XPF and XPG at 37 °C for 60 min. DNA cleavage intermediate and final product are marked. Means and standard deviations of triplicated dual incision reactions as well as individual data points are shown in the bar graph.
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