'As a woman gets older, there are increased risks of her eggs having an extra chromosome copy, which in turn results in spontaneous genetic defects'
Recently, the Singaporean Ministry of Health has implemented a new Co-funding and Medisave scheme for patients to undertake pre-implantation genetic testing of embryos in IVF treatment.
As a woman gets older, there are increased risks of her eggs having an extra chromosome copy, which in turn results in spontaneous genetic defects. Besides Down syndrome caused by an extra copy of chromosome 21, older women also have increased risks of Edwards syndrome , Patau syndrome and Klinefelter syndrome .
This may be achieved by a different type of PGT, known as PGT-A , also commonly referred to as PGS . Currently, PGT-A is still not approved as mainstream clinical treatment in Singapore, due to unclear results and a high attrition rate of 72% in local clinical trials, as reported by the Ministry of Health in 2021 . Not only is PGT-A highly-expensive, but it is also highly-invasive, as it involves drilling a hole through the embryo shell to extract cells from the embryo for genetic testing.
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