A low-carbohydrate diet appears to be an effective weight-loss intervention in liver transplant recipients with obesity as compared with a calorie-restrictive diet, according to interim findings presented at AASLD22. LiverTwitter
presented at the annual meeting of the American Association for the Study of Liver Diseases.
Siddiqui and colleagues conducted a randomized controlled trial of 27 adult liver transplant recipients with obesity for 24 weeks. The primary endpoint was change in weight, and the secondary endpoints involved metabophenotype, metabolic flexibility, mitochondrial function, and metabolic risk. The research team excluded patients with end-stage disease, terminal disease, use of weight-loss medications, pregnancy, or uncontrolled psychiatric illness that could interfere with adherence.
"We wanted to reinforce the dietary advice. We wanted to identify factors that may lead to compliance," Siddiqui said."Multiple studies have documented that the more contact that patients have during weight-loss studies with medical personnel, the more effective those strategies are."
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